Researchers show that migraine medication also helps people lose weight
Using the migraine medicine frovatriptan, researchers were able to show that obese mice lost weight. Their findings were reported in the Journal of Experimental Medicine.
The researchers built the study on prior examinations examining the links between serotonin and hunger. When it comes to your emotions and motor skills, serotonin is a chemical messenger that can make a world of difference. The role that serotonin plays in regulating hunger, however, is quite nuanced. As such, scientists have been exploring for ways to comprehend it better.
This new study grew out of such considerations. Previous research has investigated the effects of several medications on the 15 serotonin receptors known to regulate food intake. However, the effects of triptans on hunger had not been studied. Typically, we utilise triptans to treat migraines and other headaches. It appears that this medication for migraines may also aid in weight loss.
The investigators tested six prescription triptans on a variety of obese mice on high-fat diets for seven weeks. Two of the six medications had no effect. However, when the number of mice was increased to four, they began to consume less food than before. As indicated above, one particular migraine medicine proved highly successful, leading to an average weight loss of 3.6 percent body weight when provided daily for 24 days.
The fact that this migraine medication caused mice to lose weight is really interesting. Based on these findings, the team set out to create mice without the Htr1b receptor, which regulates appetite. Frovatriptan had no effect on these mice after repeated doses.
These mice no longer showed any signs of weight loss when given the migraine medication. As a result, it appears that the drug’s effect on that specific receptor is critical to the way it reduces hunger. The researchers also identified the brain cells that play a key role in the receptor’s regulation of appetite.
Potentially, this will pave the way for additional developments and choices in the field of weight loss medications. According to one of the study’s authors, frovatriptan, which is used to treat migraines, can also be used to help people lose weight. Obese mice were able to lose weight because their appetites were reduced.
If the medicine has the same impact on humans, it could help those who are having trouble maintaining a healthy weight.